Cyanobacteria are planktonic blue-green algae and performing oxygenic photosynthesis like higher plants. They can be found in various environmental sites from warmer aquatics to terrestrial, or even at Antarctic sites. Today, cyanobacteria are attractive candidates to reduction of atmospheric carbon dioxide, which is considered to be one cause of global warming and climate changes. Furthermore, they can produce large amount of metabolites, which have a broad range of application, such as human food, animal feed, cosmetics, and pharmaceuticals.
In present, the increase in available genome data is acclerating progress towards that provides insights into cyanobacterial evolution; as well as, giving new understanding into genetic background functionality and cell adaptation, which would offer new biotechnological perspectives for developing efficient cyanobacterial cells.
The comparative genomics approach was used to construct the clusters of orthologous groups of cyanobacterial proteins, CyanoCOG. With comparative genomics approach, 218,574 genes from 51 cyanobacterial genomes were clustered into 16,473 clusters, which were distributed over several processes of the cell
CyanoCOG: A database of cyanobacterial orthologous proteins was constructed from the ortholog concept, which is the analysis based on all-against-all sequence comparison among desired organisms. This web-based database provides features for users to search for protein details, compare proteins in clusters, and perform further analysis over orthologous protein clusters.
Enter CyanoCOG database
In-house gene table tool
We developed an algorithm that allows us to compare the gene contents found in multiple draft and complete genomes as shown in Figure 1.
Figure 1. An overview of our method for comparing gene contents found in multiple draft and complete genomes
Our method has been used to analyze the gene content of 100 Cyanobacteria genomes. This allows us to characterize the core as well as variable gene pools of Arthrospira as well as other Cyanobacteria species. We are currently analyzing the variations in gene contents with respect to metabolic capacities. Result from this may allow us to introduce new biosynthetic pathways from one Cyanobacteria species to other.
Start gene table tool
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